A proprietary blend of strains of Bacillus natto, Bifidobacterium, and Inulin.  Bacillus natto produces the enzyme nattokinase, which is believed to reduce blood clotting both by, direct fibrinolysis of clots, and inhibition of plasma proteins. This may help to avoid thrombosis, as for example in heart attacks, pulmonary embolism, or strokes. Bacillus Natto is also said to have an antibiotic effect and was used as medicine against dysentery by the Japanese army prior to WWll. Furthermore. Bacillus natto is known to improve digestion and reduce the incidence of acid reflux by raising the pH of the digestive system. The Bifido strains are naturally occurring strains found in the digestive tract.
Scientists have sequenced the genome of one of the most important residents in the human gastrointestinal tract, a bacterium that keeps the digestive system running smoothly, blocks the growth of harmful bacteria, and boosts the immune system. The microbe, called Bifidobacterium longum, is often the dominant bacterium found in humans.
The researchers identified a number of proteins specialized to help B. longum interact with the human host and persist against harmful bacteria. They can now closely look at which genes allow B. longum to live in different environments such as dairy products, vegetables and the human gastrointestinal tract.
Bacteria such as B. longum ferment sugars into lactic acid and have many health benefits. For these reasons, researchers of the food and drug industry have taken a keen interest in using these organisms.
Bifidobacterium longum is among the first colonizers of the sterile digestive tract of newborns and is predominate in breast-fed infants, according to the scientists. The research team isolated the bacterium from the feces of an infant. Fabrizio Arigoni, of the Swiss food and infant formula manufacturer Nestlé in Lausanne, led the study.
Formula-fed infants have a different microflora, and this may be related to the higher risk of diarrhea and allergies in these babies. “This progressive colonization is thought to be important for development of immune system tolerance…lack of such tolerance possibly leads to food allergies and chronic inflammation,” the researchers write in Proceedings of the National Academy of Sciences.
Recognizing the many benefits of lactic acid bacteria to good health, people have been supplementing their diets with these microbes, which are also called Probiotics (meaning ‘in favor of life’).
Lactic acid bacteria have been included in dairy foods and taken as supplements in powder, liquid extracts, or tablets. Namely live cultures in yogurt have been used as a remedy for hundreds of years to support immune function. Doctors recommend the bacterial supplement to patients who take antibiotics, suffer from bacterial, viral or fungal infections or have various digestive problems.
Other potential uses of B. longum are being investigated in separate studies. Japanese researchers showed that the microbe might be useful as a gene delivery vector for cancer therapy. They injected the bacterium into the tail veins of rats and demonstrated that B. longum is accumulated in the tumor.
Recent research has shown an important physiological action for inulin (Gibson, Roberfroid). Like some pectins and fructo-oligosaccharides, inulin is a preferred food for the lactobacilli in the intestine and can improve the balance of friendly bacteria in the bowel. Subjects in one trial were give 15 grams of inulin a day for fifteen days. Lactobacillus Bifidobacterium increased by about 10% during that period. Gram-positive bacteria associated with disease declined. Bifidobacterium digest inulin to produce short chain fatty acids, such as acetic, propionic, and butyric acids. The liver for energy production may use the first two, while butyric acid has cancer-preventing properties within the intestine (Spiller, 1994). Recent animal research also shows that inulin prevents precancerous changes in the colon (Reddy, 1997).